Improved Stem Cell-Derived Motoneuron Survival, Migration, Sprouting, and Innervation with Enhanced Expression of Polysialic Acid
نویسندگان
چکیده
منابع مشابه
Chemically primed bone-marrow derived mesenchymal stem cells show enhanced expression of chemokine receptors contributed to their migration capability
Objective(s):The limited homing potential of bone-marrow-derived mesenchymal stem cells (BM-MSC) is the key obstacle in MSC-based therapy. It is believed that chemokines and chemokine receptor interactions play key roles in cellular processes associated with migration. Meanwhile, MSCs express a low level of distinct chemokine receptors and they even lose these receptors on their surface after a...
متن کاملPromoting the survival, migration and integration of Schwann cells by over-expression of polysialic acid
....................................................................................... 2 Acknowledgements ........................................................................... 4 Statement of original contributions .............................................. 5 List of abbrevations ...................................................................... 6 Table of contents ..................
متن کاملchemically primed bone-marrow derived mesenchymal stem cells show enhanced expression of chemokine receptors contributed to their migration capability
objective(s):the limited homing potential of bone-marrow-derived mesenchymal stem cells (bm-msc) is the key obstacle in msc-based therapy. it is believed that chemokines and chemokine receptor interactions play key roles in cellular processes associated with migration. meanwhile, mscs express a low level of distinct chemokine receptors and they even lose these receptors on their surface after a...
متن کاملEnhanced expression of polysialic acid correlates with malignant phenotype in breast cancer cell lines and clinical tissue samples.
Polysialic acid (PSA) is highly expressed during embryonic development, but barely expressed during postnatal development, and may be 're-expressed' in cancer tissues. In this study, motility and migration assays were performed to compare the changes in cell behavior between non-malignant and maligant cells. Next, the expression levels of PSA were evaluated in 4 human and mouse normal breast or...
متن کاملEnhancement of polysialic acid expression improves function of embryonic stem-derived dopamine neuron grafts in Parkinsonian mice.
There has been considerable progress in obtaining engraftable embryonic stem (ES) cell-derived midbrain dopamine neurons for cell replacement therapy in models of Parkinson's disease; however, limited integration and striatal reinnervation of ES-derived grafts remain a major challenge for future clinical translation. In this paper, we show that enhanced expression of polysialic acid results in ...
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ژورنال
عنوان ژورنال: Cell Transplantation
سال: 2015
ISSN: 0963-6897,1555-3892
DOI: 10.3727/096368914x679228